Artificially designed promoters
نویسندگان
چکیده
منابع مشابه
An artificially designed pore-forming protein with anti-tumor effects.
Protein engineering is an emerging area that has expanded our understanding of protein folding and laid the groundwork for the creation of unprecedented structures with unique functions. We previously designed the first native-like pore-forming protein, small globular protein (SGP). We show here that this artificially engineered protein has membrane-disrupting properties and anti-tumor activity...
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متن کاملAssembly PCR synthesis of optimally designed, compact, multi-responsive promoters suited to gene therapy application
Gene therapy has the potential to provide innovative treatments for genetic and non-genetic diseases, with the ability to auto-regulate expression levels of therapeutic molecules so that they are produced locally and in direct response to disease activity. Generating disease responsive gene therapy vectors requires knowledge of the activation profile of transcription factors (TFs) during active...
متن کاملthousands of designed sequences Probing the effect of promoters on noise in gene expression using
Genetically identical cells exhibit large variability (noise) in gene expression, with important consequences for cellular function. Although the amount of noise decreases with and is thus partly determined by the mean expression level, the extent to which different promoter sequences can deviate away from this trend is not fully known. Here, we present a high-throughput method for measuring pr...
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ژورنال
عنوان ژورنال: Bioengineered
سال: 2012
ISSN: 2165-5979,2165-5987
DOI: 10.4161/bbug.18530